Sergei Kulkov
Institute of Strength Physics and Materials Science SB RAS, Russia
Title: Porous composite materials ZrO2(Mg)-MgO for biomedical applications
Biography
Biography: Sergei Kulkov
Abstract
Applications of ceramics for biomedical usages had a special interest now. The most actively developed studies in this area are investigations of zirconia ceramic included in ISO register as a material for bone replacement. Ceramics based on zirconia stabilized with magnesium oxide is involved in protein synthesis and DNA processes, stabilization of DNA molecules, RNA and ribosomes. In this paper were studied pore structure and phase composition of ceramic composite material ZrO2(Mg)-MgO at different sintering temperatures. It has been shown that during sintering of porous ceramic were formed bimodal porosity structure with mean size 26-30 and 94-110 µm. It has been shown that main mechanical characteristics of the material were determined and it was shown, that they are close to the characteristics of natural bone tissues. Ceramic strength directly depends on microstresses and at high microstresses ceramic has a low strength. In vitro studies were shown that the tested materials are not cytotoxic, cultured MMS cells on the surface of the samples have high viability and osteogenic differentiation ability, and the presence of cell clusters in the pores of the samples may indicate their proliferation.
