Zeinab Fereshteh
Isfahan University of Technology, Iran
Title: Modification of Mg-doped fluoridated hydroxyapatite nanoparticles by amino acids as a drug delivering nanobio-polymer composite for tissue engineering
Biography
Biography: Zeinab Fereshteh
Abstract
In the past few years, hydroxyapatite (HA) has been widely used as a bioactive ceramic. Not only does the development of modified-HA by the substitution of Ca ions and OH groups make its chemical composition similar to that of the natural bone tissue, but also improves the in vitro behavior of commercially synthesized HA. Aiming at such capabilities, magnesium-fluoridated hydroxyapatite nanoparticles (Mg-FHA NPs) have been recently developed. But, NPs have high surface energy and therefore, they cannot be well dispersed in a bio-polymer matrix to prepare a polymer/ceramic composite, which is usually required for tissue engineering applications. To resolve this problem, we aimed to modify the surface of Mg-FHA NPs using a few well-known natural amino acids as the cost-effective and environment-friendly bio-materials. As coupling agents, L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-tyrosine and L-valine amino acids were employed and by performing the sonication technique the surface Mg-FHA NPs was modified. The results confirmed that using amino acid molecules led to uniform dispersion of Mg-FHA NPs in the organic environment by making the surface of NPs hydrophobic, although the length and chemical reactivity of amino acid molecules affected the efficiency of NPs dispersion. The uniform distribution of Mg-FHA NPs could be regarded as a desired condition for polymer/ceramic composite preparation with high applicability for biomedical purposes.